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Effect of Fasting Subjects’ Posture on 13 C‐Urea Breath Test for Detection of Helicobacter pylori Infection
Author(s) -
Miwa Hiroto,
Murai Toshio,
Ohkura Ryuichi,
Kawabe Masato,
Tanaka Hiroshi,
Ogihara Tatsuo,
Watanabe Sumio,
Sato Nobuhiro
Publication year - 1997
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/j.1523-5378.1997.tb00063.x
Subject(s) - urea breath test , breath test , helicobacter pylori infection , helicobacter pylori , test (biology) , medicine , urea , gastroenterology , chemistry , biology , biochemistry , paleontology
Background. Although many factors that may affect the 13 C‐urea value have been verified, no literature is available regarding the effect of the posture of the patient on the shape of the Δ 13 C excretion curve. In an effort to contribute to the development of a simple and standard procedure for the 13 C‐urea breath test, we investigated whether either the posture of the patient during the procedure or the mouthwash after dosing affects the shape of the Δ 13 C excretion curve. Materials and Methods. Seventy‐two Helicobacter pylori –infected subjects were divided into four groups according to the position during procedure and the mouthwash after dosing: group A, in the supine position with mouthwash; group B, in the sitting position with mouthwash; group C, changed position by rolling with mouthwash; and group D, changed position (as did group C) without mouthwash. Absolute values of Δ 13 C at each sampling point were compared in the four groups. Results. Δ 13 C values in group A gradually increased until the 15‐minute point; those in group B were almost stable from 5 to 30 minutes, and those in group C peaked at the 5‐minute point, then decreased until 30 minutes, the values becoming similar at the 20‐minute point. Significant differences were seen between groups A, B, C, and D at the 5‐ and 10‐minute points. Conclusion. These results suggest that posture and mouthwash affect Δ 13 C value at the 5‐ and 10‐minute points. Sampling at 20 (maybe 15 or 30) minutes for fasting patients in a sitting position is considered to be appropriate for detection of H. pylori infection in a standard two‐sampling‐point 13 C‐urea breath test.