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Predictive Factors for Relapse in Patients on Buprenorphine Maintenance
Author(s) -
Ferri Michael,
Finlayson Alistair J. Reid,
Wang Li,
Martin Peter R.
Publication year - 2013
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.2013.12074.x
Subject(s) - buprenorphine , logistic regression , medicine , opioid , opiate substitution treatment , opioid use disorder , substance abuse , benzodiazepine , anxiety , retrospective cohort study , psychiatry , emergency medicine , receptor
Background and Objectives Despite the dramatic increase in the use of buprenorphine for the treatment of opioid dependence, clinical outcomes of this treatment approach continue to need evaluation. This study examines factors associated with relapse and retention during buprenorphine treatment in a sample of opioid dependent outpatients. Methods In a retrospective chart review of 62 patients with opioid dependence, relapse was determined by self‐report, urine toxicology screens, and by checking the state controlled substance monitoring database. Data was analyzed using two‐way tests of association and logistic regression. Results Patients with comorbid anxiety disorders, active benzodiazepine use (contrary to clinic policy), or active alcohol abuse, were significantly more likely to relapse. Patients who relapsed were also more likely to be on a higher buprenorphine maintenance dose. Conclusion This study identifies relapse risk factors during buprenorphine treatment for opioid dependence. Future research is needed to determine whether modifying these factors may lead to improved treatment outcomes. (Am J Addict 2014;23:62–67)