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Genetic Association of GABA‐A Receptor Alpha‐2 and Mu Opioid Receptor with Cocaine Cue‐Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence
Author(s) -
Smelson David,
Yu Lei,
Buyske Steven,
Gonzalez Gerardo,
Tischfield Jay,
Deutsch Curtis K.,
Ziedonis Douglas
Publication year - 2012
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.2012.00253.x
Subject(s) - craving , μ opioid receptor , cue reactivity , cocaine dependence , psychology , opioid receptor , opioid , single nucleotide polymorphism , receptor , pharmacology , medicine , neuroscience , gene , genetics , biology , genotype , addiction
Background:This pilot feasibility study examined the role of genetics in laboratory‐induced cocaine craving.Methods: Thirty‐four African American, cocaine‐depend‐
ent male subjects underwent a baseline assessment, cue‐exposure session, and genetic analysis. Subjects were classified as either cue‐reactive or nonreactive.Results:Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue‐reactivity, two were statistically significant: GABRA2 (coding for GABA‐A receptor alpha‐2 subunit; rs11503014, nominal p = .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p = .03).Conclusions: These pilot results suggest that cocaine craving shows variability among cocaine‐dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue‐reactivity, warranting studies in future research. (Am J Addict 2012;21:411–415)