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Conducting Clinical Research with Prescription Opioid Dependence: Defining the Population
Author(s) -
Weiss Roger D.,
Potter Jennifer S.,
Copersino Marc L.,
Prather Kristi,
Jacobs Petra,
Provost Scott,
Chim David,
Selzer Jeffrey,
Ling Walter
Publication year - 2010
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.2009.00017.x
Subject(s) - medical prescription , heroin , addiction , opioid , population , psychiatry , medicine , psychology , pharmacology , drug , receptor , environmental health
Most treatment studies of opioid‐dependent populations have focused predominantly on heroin users, despite a recent increase in those dependent upon prescription opioids. A key methodological challenge involved in studying the latter group involves defining the population. Specifically, researchers must decide whether to include (1) concurrent heroin users and (2) individuals with pain. The multi‐site Prescription Opioid Addiction Treatment Study is examining treatments for this population. This paper describes various inclusion criteria considered by the study team related to heroin use and pain. The goal was to recruit a distinct but generalizable population of individuals dependent upon prescription opioids. (Am J Addict 2010;00:1–6)