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Drug Interactions between Antiretroviral Medications and Medications Used in the Treatment of Drug Addiction: Research Needs
Author(s) -
Khalsa Jag H.,
Elkashef Ahmed
Publication year - 2009
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.2009.00010.x
Subject(s) - drug , addiction , medicine , substance abuse , psychiatry , population , intensive care medicine , public health , pharmacodynamics , pharmacology , pharmacokinetics , environmental health , nursing
Today substance dependence is one of the major public health problems in the world with millions of people abusing legal and illegal drugs. In addition, almost one‐third of the world's population suffers with one or more infections. Both drugs of abuse and infections are associated with serious medical and health consequences, some of which may be exacerbated by the occurrence of pharmacokinetic and/or pharmacodynamic interactions between medications used in the treatment of these conditions when they co‐occur. This review briefly discusses issues surrounding clinical management related to drug interactions experienced by substance abusing patients. The emphasis of this paper is on the research needed to further study the extent, nature, and underlying molecular/genetic mechanism(s) of interactions between drugs of abuse, medications used in the treatment of drug addiction, and co‐occurring infections. (Am J Addict 2009;19:96–100)