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Effect of Cocaine Use on Methadone Pharmacokinetics in Humans
Author(s) -
McCanceKatz Elinore F.,
Jatlow Peter,
Rainey Petrie M.
Publication year - 2009
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.2009.00009.x
Subject(s) - methadone , pharmacokinetics , buprenorphine , cocaine use , medicine , anesthesia , cocaine dependence , opioid , adverse effect , addiction , drug , methadone maintenance , pharmacology , psychiatry , receptor
Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in Cmin (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure. (Am J Addict 2009;19:47–52)