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Craving for Cocaine in Addicted Users
Author(s) -
BuydensBranchey Laure,
Branchey Marc,
Fergeson Paul,
Hudson Jeffrey,
McKernin Craig
Publication year - 1997
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1997.tb00393.x
Subject(s) - craving , psychology , addiction , psychotherapist , psychiatry
Very few studies have examined the role of serotonin (5‐HT) in the modulation of craving for cocaine in cocaine‐addicted persons. The authors evaluated whether the acute increase in serotonergic neurotransmission after the administration of a challenging dose of the 5‐HT partial agonist meta‐chlorophenylpiperazine (m‐CPP) had an effect on spontaneous cocaine craving. Male inpatients (N = 31) who met DSM‐III‐R criteria for cocaine dependence completed 2 days of testing (separated by 48 hours) that involved the oral administration of m‐CPP (0.5 mg/kg of body weight) or placebo in random order and under double‐blind conditions. Patients' craving for cocaine was found to decrease significantly after the administration of m‐CPP. These data could provide evidence for a modulation of cocaine craving by 5‐HT systems.