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Cardiovascular Interactions of Desipramine, Fluoxetine, and Cocaine in Cocaine‐Dependent Outpatients
Author(s) -
Nelson Richard A.,
Gorelick David A.,
Keenan Robert M.,
Carmona Gilberto N.,
Covi Lino
Publication year - 1996
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1996.tb00318.x
Subject(s) - desipramine , fluoxetine , cocaine dependence , cocaine use , psychology , cocaine abuse , medicine , pharmacology , psychiatry , anesthesia , antidepressant , addiction , serotonin , receptor , anxiety
The authors investigated the subacute cardiovascular effects of cocaine use alone and with antidepressants. At study entry, 55 cocaine‐dependent (DSM‐III‐R) patients with cocaine‐positive urines had slightly higher resting heart rates and blood pressures than 36 patients with cocaine‐negative urines, which achieved significance (P < 0.05) for three of eleven parameters. A repeated‐measures analysis of medication‐compliant patients found no significant cardiovascular differences between cocaine‐positive and cocaine‐negative urine conditions for either desipramine (n = 10) or fluoxetine (n = 20). Cocaine use appears to produce minimal subacute cardiovascular effects, which are not accentuated by desipramine or fluoxetine, in physically healthy cocaine‐dependent patients. (American Journal on Addictions 1996; 5:321–326)