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Predictors of Antidepressant Response in Depressed Alcoholic Patients
Author(s) -
Nunes Edward V.,
McGrath Patrick J.,
Quitkin Frederic M.,
Stewart Jonathan W.,
Goehl Leslie,
OcepekWelikson Katja
Publication year - 1996
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1996.tb00316.x
Subject(s) - sobriety , depression (economics) , antidepressant , psychiatry , hamilton rating scale for depression , rating scale , panic , mood , psychology , panic disorder , clinical psychology , addiction , imipramine , medicine , major depressive disorder , anxiety , alternative medicine , developmental psychology , economics , macroeconomics , pathology
Sixty alcoholic patients with depressive disorders completed a 12‐week, open‐label trial of imipramine; 27 (45%) had a favorable response, defined as substantial improvement in both mood and sobriety. The authors examine demographic and clinical predictors of response. Responders were less likely to be minorities, bad lower Hamilton Rating Scale for Depression scores, fewer maximum drinks per day at baseline, and were somewhat more likely to have panic disorder. The authors discuss implications for the selection of alcoholic patients for antidepressant treatment. (American Journal on Addictions 1996; 5:308–312)