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Safety and Efficacy of Bupropion Combined With Bromocriptine for Treatment of Cocaine Dependence
Author(s) -
Montoya Ivan D.,
Preston Kenzie L.,
Cone Edward J.,
Rothman Richard.,
Gorelick David A.
Publication year - 1996
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1996.tb00286.x
Subject(s) - bupropion , bromocriptine , medicine , cocaine dependence , adverse effect , pharmacology , anesthesia , psychology , psychiatry , addiction , smoking cessation , prolactin , hormone , pathology
Bupropion and bromocriptine have been used separately for treatment of cocaine dependence. This 8‐week, open‐label study tested the combination of bupropion and bromocriptine with the goal of obtaining an enhanced therapeutic effect with fewer side effects. Thirteen cocaine‐dependent (DSM‐III‐R criteria) subjects received bupropion (≤300 mg) plus bromocriptine (≤7.5 mg) daily, in addition to weekly individual standardized counseling. No serious adverse events were reported. There were significant (P < 0.01) reductions between pretreatment and posttreatment for patients' self‐reported weekly grams used, money spent on cocaine, and Beck Depression Inventory score; however, there were no significant changes in the results of urine toxicology tests for cocaine (qualitative and quantitative) or self‐reported drug craving. These results suggest that the combination of bupropion and bromocriptine may be safe and have some efficacy in treatment of cocaine dependence.