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A Comparison of Pergolide and Bromocriptine in the Initial Rehabilitation of Cocaine Dependence
Author(s) -
Malcolm Robert,
Phillips Joem D.,
Brady Kathleen T.,
Roberts John R.
Publication year - 1994
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1994.tb00381.x
Subject(s) - pergolide , bromocriptine , medicine , cocaine dependence , anesthesia , dopamine agonist , dopamine , psychology , addiction , psychiatry , prolactin , hormone , dopaminergic
Numerous pharmacologic agents have been used in an attempt to improve treatment outcome for cocaine‐dependent individuals. In this study, 41 men and women newly admitted to a 30‐day inpatient treatment program for cocaine dependence were randomized to open treatment with pergolide or bromocriptine (two dopamine agonists) or a no‐medication group. Treatment groups were compared for mean length of stay in the hospital (MLS), number of discharges against medical advice (AMA), and on a self‐report visual analog craving scale prior to treatment and again between Day 7 and Day 10. The pergolide and bromocriptine groups both had an MLS of 25 days, with one AMA discharge (6%). The no‐medication treatment group had an MLS of 16.2 days and four (36%) AMA discharges. Mean decrease in the craving scores in the pergolide group was 31.8, in the bromocriptine group, 24.0, and in the no‐medication group, 7.9.