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Cocaine Use in Buprenorphine‐ vs. Methadone‐Maintained Patients
Author(s) -
Oliveto Alison H.,
Kosten Thomas R.,
Schottenfeld Richard,
Ziedonis Douglas,
Falcioni Jean
Publication year - 1994
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1994.tb00225.x
Subject(s) - buprenorphine , methadone , urinalysis , medicine , opiate , opioid , anesthesia , addiction , randomized controlled trial , cocaine dependence , opiate substitution treatment , psychiatry , urine , receptor
The authors examined cocaine use in 110 opioid‐dependent cocaine users during a 24‐week, randomized, double‐blind clinical trial in which patients were maintained daily on one of the following: 2 mg of buprenorphine, 6 mg of buprenorphine, 35 mg of methadone, or 65 mg of methadone. During the 24‐week trial, cocaine use, as measured by urinalysis and self‐reports, did not differ across medication groups, although opiate use decreased significantly in the methadone groups relative to the buprenorphine groups. These results suggest that buprenorphine, at doses up to 6 mg/day, is not more effective than methadone in decreasing cocaine use in opioid‐dependent cocaine users. (American Journal on Addictions 1994; 3:43–48)