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Electroencephalographic Evidence for Residual CNS Hyperexcitability During Cocaine Abstinence
Author(s) -
Bauer Lance O.
Publication year - 1993
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1993.tb00431.x
Subject(s) - abstinence , audiology , psychology , medicine , psychiatry
The author evaluated visual steady‐state evoked responses (SSER) and auditory amplitude‐modulated following responses (AMFR) in 13 cocaine‐dependent patients, 5 alcohol‐dependent patients, and 12 non–drug‐dependent control subjects. The 18 patients were studied after 1, 3, and 12 weeks of verified abstinence; the controls were studied after comparable intervals. Analyses revealed that visual SSER power increased as a function of modulation depth in the cocaine‐dependent group, but not in the other groups. The difference among the groups was greatest at the highest modulation depth (80%) and did not diminish over time. Auditory AMFR power was also greater in the cocaine‐dependent group relative to the other groups. However, unlike the visual SSER, the auditory AMFR normalized with continued cocaine abstinence. Collectively, the SSER and AMFR findings are interpreted as reflecting a residual cocaine effect which heightens CNS reactivity to sine wave (but not square wave)‐modulated visual and auditory input.