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Six‐Month Follow‐Up of Short‐Term Pharmacotherapy for Cocaine Dependence
Author(s) -
Kosten Thomas R.,
Gawin Frank H.,
Kosten Therese A.,
Morgan Cindy,
Rounsaville Bruce J.,
Schottenfeld Richard,
Kleber Herbert D.
Publication year - 1992
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1111/j.1521-0391.1992.tb00005.x
Subject(s) - desipramine , abstinence , pharmacotherapy , placebo , cocaine dependence , medicine , alcohol dependence , randomized controlled trial , depression (economics) , placebo group , anesthesia , lithium (medication) , psychiatry , antidepressant , alcohol , addiction , anxiety , biochemistry , chemistry , alternative medicine , macroeconomics , pathology , economics
This 6‐month follow‐up study of 43 of 72 patients who entered a 6‐week randomized clinical trial of pharmacotherapy for cocaine dependence found that self‐reported cocaine abstinence during the 6 months was significantly greater in patients treated with desipramine (44%) than in those treated with lithium (19%) or placebo (27%). The placebo group had more occurrences of depression (36% vs. 6%) and daily alcohol abuse (36% vs. 15%) than the medicated groups. The ability to abstain from cocaine use during the clinical trial was the strongest predictor of continued abstinence during the follow‐up, which showed that 53% remained abstinent after 6 months.