Open AccessDiscordant Hemodynamic and Fibrinolytic Adaptations Following a 6‐Week Cardiac Rehabilitation Program
Author(s) -
Nagelkirk Paul R.,
Franklin Barry A.,
Coughlin Adam M.,
Hassouna Houria I.,
Fink Gregory D.,
Pivarnik James M.,
Womack Christopher J.
Publication year - 2007
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1520-037x.2007.06425.x
Subject(s) - medicine , fibrinolysis , hemodynamics , blood pressure , plasminogen activator , rehabilitation , heart rate , analysis of variance , tissue plasminogen activator , repeated measures design , cardiology , plasminogen activator inhibitor 1 , physical therapy , statistics , mathematics
The present study evaluated changes in hemodynamics and fibrinolysis during 6 weeks of participation in an exercise‐based cardiac rehabilitation program. Fourteen patients trained for 3 days per week for 6 weeks using American College of Sports Medicine guidelines for intensity and duration. Blood samples were taken at baseline and after 3 and 6 weeks of participation and analyzed for tissue plasminogen activator (t‐PA) activity and antigen, plasminogen activator inhibitor‐1 (PAI‐1) activity and antigen, and relative quantification of t‐PA and PAI‐1 RNA. Data were analyzed using repeated measures analysis of variance. Training elicited significant decreases in submaximal exercise heart rate and systolic blood pressure and resting systolic blood pressure ( p <.05). There were no significant changes in plasma concentrations of t‐PA or PAI‐1, and no change was observed in t‐PA or PAI‐1 gene expression. The present findings suggest that favorable hemodynamic adaptations may occur after only 6 weeks of exercise‐based cardiac rehabilitation, but longer training periods may be needed to elicit positive hemostatic adaptations.