Open AccessThe Acute Effect of Aerobic Exercise on Brachial Artery Endothelial Function in Renal Transplant Recipients
Author(s) -
CosioLima Ludmila M.,
Thompson Paul D.,
Reynolds Katy L.,
Headley Samuel A.,
Winter Christa R.,
Manos Tina,
Lagasse Marie A.,
Todorovich John R.,
Germain Michael
Publication year - 2006
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1520-037x.2006.05408.x
Subject(s) - medicine , brachial artery , cardiology , aerobic exercise , renal function , renal transplant , physical therapy , transplantation , blood pressure
This study compared the effect of a 30‐minute walk on brachial artery endothelial vasodilatation in kidney transplant (KT) recipients and healthy controls (HCs). Endothelial‐dependent vasodilatation was measured by ultrasound before and after exercise. The HCs experienced a significant increase in vasodilatation after exercise 1 minute postocclusion when compared with the KT recipients (22%±13% vs 3%±4%; V<.05). Also, the HCs had a significantly higher vasodilatation from pretreadmill walk to post‐treadmill walk (1 minute postocclusion) when compared with KT recipients (from 3%±6% to 22%±13% vs 1%±3% to 3%±4%; V<.05). This acute vasodilatory response observed in the HCs may be related to the immediate release of nitric oxide and the combined response to shear stress and exercise. The KT recipients had several coronary artery disease risk factors that may have adversely affected endothelial function.