Open AccessWalking and Non‐HDL‐C in Adults: A Meta‐Analysis of Randomized Controlled Trials
Author(s) -
Kelley George A.,
Kelley Kristi S.,
Tran Zung Vu
Publication year - 2005
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1520-037x.2005.3474.x
Subject(s) - medicine , meta analysis , confidence interval , randomized controlled trial , random effects model , meta regression , standard error , physical therapy , cholesterol , statistics , mathematics
An elevated level of non‐high‐density lipoprotein cholesterol (non‐HDL‐C) is a major risk factor for cardiovascular disease. The purpose of this study was to use the meta‐analytic approach to examine the effects of walking on non‐HDL‐C in adults. Twenty‐two randomized controlled trials representing 30 outcomes from 948 subjects (573 exercise, 375 control) met our inclusion criteria. Across all designs and categories, random effects modeling resulted in a significantly greater decrease in the walking group when compared with the control group of approximately 4% for non‐HDL‐C (± standard error of the mean, −5.6±1.8 mg/dL, 95% confidence interval, −8.8 to −2.4 mg/dL). Meta‐regression showed a statistically significant association between changes in non‐HDL‐C and the year of publication, with greater reductions associated with more recent publication year (R2=0.23, p=0.005). The results of this meta‐analytic review suggest that walking reduces non‐HDL‐C in adult humans.