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Valproate Prevents Epileptiform Activity After Trauma in an In Vitro Model in Neocortical Slices
Author(s) -
Luojia Yang,
Larry S. Benardo
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1499-1654.2000.001507.x
Subject(s) - epileptogenesis , neocortex , anesthesia , valproic acid , epilepsy , medicine , extracellular , neuroscience , pharmacology , inhibitory postsynaptic potential , chemistry , psychology , biochemistry
Epileptogenesis is a hallmark of severe cortical trauma, with up to approximately 80% of patients experiencing seizures in the first 24 hours after penetrating head injury. An in vitro model of traumatic brain injury was developed to investigate hyperexcitability and epileptogenesis and their prevention. We determined whether sodium valproate would prevent epileptiform activity in this experimental model.