Open AccessDecision making and addictive behaviors in narcolepsy with cataplexy
Author(s) -
Bayard Sophie,
Dauvilliers Yves
Publication year - 2013
Publication title -
sleep and biological rhythms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.371
H-Index - 30
eISSN - 1479-8425
pISSN - 1446-9235
DOI - 10.1111/j.1479-8425.2012.00555.x
Subject(s) - narcolepsy , cataplexy , orexin , addiction , neuroscience , psychology , wakefulness , modafinil , neuroimaging , neurology , addictive behavior , sleep (system call) , medicine , psychiatry , neuropeptide , electroencephalography , receptor , computer science , operating system
Narcolepsy with cataplexy (NC) is caused by the loss of hypothalamic neurons that produce hypocretins (also known as orexins). The hypocretin system plays a crucial role in sleep, wakefulness, and energy homeostasis. Behavioral, anatomical and neurophysiological studies in animals have shown that hypocretins are involved in reward and addictive behaviors. Recently neuroimaging and behavioral studies indicated that reward‐processing and decision‐making networks are also altered in hypocretin‐deficient narcoleptic patients. These evidences offer new research directions to our understanding of the role of hypocretins in reward and addiction.