Open AccessGlycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes
Author(s) -
YAMADERA Wataru,
INAGAWA Kentaro,
CHIBA Shintaro,
BANNAI Makoto,
TAKAHASHI Michio,
NAKAYAMA Kazuhiko
Publication year - 2007
Publication title -
sleep and biological rhythms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.371
H-Index - 30
eISSN - 1479-8425
pISSN - 1446-9235
DOI - 10.1111/j.1479-8425.2007.00262.x
Subject(s) - bedtime , polysomnography , sleep onset , sleep (system call) , sleep onset latency , slow wave sleep , insomnia , hypnotic , ingestion , psychology , medicine , sleep stages , anesthesia , audiology , psychiatry , electroencephalography , computer science , operating system , apnea
In human volunteers who have been continuously experiencing unsatisfactory sleep, effects of glycine ingestion (3 g) before bedtime on subjective sleep quality were investigated, and changes in polysomnography (PSG) during sleep were analyzed. Effects on daytime sleepiness and daytime cognitive function were also evaluated. Glycine improved subjective sleep quality and sleep efficacy (sleep time/in‐bed time), and shortened PSG latency both to sleep onset and to slow wave sleep without changes in the sleep architecture. Glycine lessened daytime sleepiness and improved performance of memory recognition tasks. Thus, a bolus ingestion of glycine before bedtime seems to produce subjective and objective improvement of the sleep quality in a different way than traditional hypnotic drugs such as benzodiazepines.