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TCF7L2 polymorphism and cognitive test performance in cardiovascular disease
Author(s) -
KEARY Therese Anne,
GUNSTAD John,
BENITEZ Andreana,
SPITZNAGEL Mary Beth,
MCCAFFERY Jeanne,
MCGEARY John E.,
POPPAS Athena,
PAUL Robert H.,
SWEET Lawrence H.,
COHEN Ronald A.
Publication year - 2012
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/j.1479-8301.2011.00398.x
Subject(s) - psychomotor learning , tcf7l2 , cognition , genotype , neuropsychology , executive functions , disease , medicine , polymorphism (computer science) , psychology , audiology , clinical psychology , single nucleotide polymorphism , psychiatry , biology , genetics , gene
Aims: The present study examines cognitive function among transcription factor 7‐like 2 (TCF7L2) genotype groups in a sample of older adults with cardiovascular disease. Methods: We recruited 111 older adults with diagnosed cardiovascular disease from outpatient cardiology clinics. Neuropsychological tests assessed the following domains of cognitive functioning: global function, attention/executive/psychomotor speed, learning and memory, visuospatial/construction, motor, and language. Genotyping of TCF7L2 single nucleotide polymorphism rs7903146 was conducted to determine membership in the TT, CT, or CC genotype groups. Results: Controlling for diabetes status, participants with the TT genotype of TCF7L2 ( n = 12) performed worse on tests of attention/executive function/processing speed than those with the CC ( n = 46) and CT ( n = 53) genotypes, despite no between‐group differences in demographic or medical variables. Conclusions: Older cardiovascular disease patients with the TCF7L2 TT genotype performed worse on tests of attention/executive/ psychomotor speed than CC and CT genotype carriers. Further work using neuroimaging and glucose tolerance indices is needed to clarify underlying mechanisms.