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Dementia in Parkinson's Disease: Its Incidence and a Possible Relationship with Dopa‐refractory Symptoms
Author(s) -
Takeda Atsushi,
Fujihara Kanae,
Kikuchi Akio,
Kimpara Teiko,
Itoyama Yasuto
Publication year - 2001
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/j.1479-8301.2001.tb00005.x
Subject(s) - dementia , parkinson's disease , disease , medicine , incidence (geometry) , executive functions , psychiatry , pediatrics , cognition , optics , physics
Background : The diagnostic criteria for dementia in idiopathic Parkinson's disease (PD) remain controversial. In PD, general intelligence is relatively spared, although executive function is commonly impaired. Methods : Following the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM‐IV), in this study we defined dementia in PD as a combined impairment of memory and executive function, and evaluated its incidence and its relationship with other clinical features. Results : The prevalence of dementia among patients with PD was estimated to be 20–30% in an outpatient clinic and was found to be associated with the severity of motor impairments, especially Dopa‐refractory symptoms. On the other hand, no relationships were observed between the prevalence of dementia and patient age or age of onset. Conclusion : These data suggest that cognitive deficits, comprising dementia syndrome in PD, are mainly due to common neurodegenerative processes of non‐dopaminergic systems, but not to other concomitant diseases, such as Alzheimer's disease.