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No Association between Presenilin 1 Intron Gene or Butyrylcholinesterase K Variant and Alzheimer's Disease in Japanese Populations
Author(s) -
Yamamoto Yasuji,
Sengo Masahito,
Yasuda Minoru,
Maeda Kiyoshi
Publication year - 2001
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/j.1479-8301.2001.tb00004.x
Subject(s) - apolipoprotein e , allele , presenilin , genetics , butyrylcholinesterase , allele frequency , polymorphism (computer science) , medicine , alzheimer's disease , age of onset , genotype , disease , biology , gene , acetylcholinesterase , enzyme , aché , biochemistry
Background : One of the purposes of this study was to examine whethe apolipoprotein E (ApoE) ɛ4 allele as a risk factor for Alzheimer's disease (AD) may be associated with the higher prevalence of AD in women compared with men. Recently, the polymorphic K variant of the butyrylcholinest erase (BChE‐K) gene and presenilin 1 (PS1) intronic polymorphism have been reported to be associated with AD respectively. Thus we have reexamined the frequency of BChE‐K, PS1 intronic polymorphism, and the ApoE ɛ4 allele in a large series of Japanese AD patients and controls. Methods : We have genotyped a large series of Japanese AD and age‐and sex‐matched controls by the method of polymerase chain reaction and restriction fragment length polymorphism for ApoE, BChE‐K, and PS1 intronic polymorphism. Results : The frequency of ApoE ɛ4 allele was significantly higher in AD patients than in controls, confirming the previous reports. In comparison between men and women, the number of individuals carrying one ɛ4 allele was much greater in women with AD than in men with this illness. Kaplan‐Meier analyses, plotting the ɛ4 gene doses against age of onset for men and women, revealed significant differences in age‐of‐onset curves between men and women.