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Vitamin D status and its predictive factors in pregnancy in 2 Australian populations
Author(s) -
PERAMPALAM Sumathy,
GANDA Kirtan,
CHOW KerriAnne,
OPIE Nicole,
HICKMAN Peter E.,
SHADBOLT Bruce,
HENNESSY Annemarie,
GRUNSTEIN Harry,
NOLAN Christopher J.
Publication year - 2011
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2011.01313.x
Subject(s) - pregnancy , medicine , obstetrics , biology , genetics
Background:  High prevalence rates of suboptimal vitamin D levels have been observed in women who are not considered ‘at risk’. The effect of behavioural factors such as sun exposure, attire, sunscreen use and vitamin D supplementation on vitamin D levels in pregnancy is unknown. Aim:  To determine prevalence and predictive factors of suboptimal vitamin D levels in 2 antenatal clinics in Australia – Campbelltown, NSW and Canberra, ACT. Methods:  A cross‐sectional study of pregnant women was performed with a survey of demographic and behavioural factors and a mid‐pregnancy determination of maternal vitamin D levels. Results:  The prevalence of vitamin D deficiency (≤25 nmol/L) and insufficiency (26–50 nmol/L) was 35% in Canberra ( n  = 100) and 25.7% in Campbelltown ( n  = 101). The majority of participants with suboptimal D levels had vitamin D insufficiency. Among the vitamin D‐deficient women, 38% were Caucasian. Skin exposure was the main behavioural determinant of vitamin D level in pregnancy in univariate analysis. Using pooled data ethnicity, season, BMI and use of vitamin D supplements were the main predictive factors of suboptimal vitamin D. Vitamin D supplementation at 500 IU/day was inadequate to prevent insufficiency. Conclusions:  Behavioural factors were not as predictive as ethnicity, season and BMI. As most participants had one of the predictive risk factors for suboptimal vitamin D, a case could be made for universal supplementation with a higher dose of vitamin D in pregnancy and continued targeted screening of the women at highest risk of vitamin D deficiency.

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