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Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women
Author(s) -
MA Linlin,
LIN Shouqing,
CHEN Rong,
ZHANG Ying,
CHEN Fengling,
WANG Xiuli
Publication year - 2010
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2010.01137.x
Subject(s) - medicine , placebo , vitex , placebo group , abdominal pain , therapeutic effect , randomized controlled trial , traditional medicine , alternative medicine , pathology
Objectives: To assess therapeutic effect of an extract of Vitex agnus castus (VAC, BNO 1095) in premenstrual syndrome (PMS) in Chinese women. Design: It was a prospective, randomised, double‐blind, placebo‐controlled study carried out in China. Eligible patients were treated with VAC extract or placebo for three cycles. Symptoms were documented with PMS diary (PMSD), a daily rating scale with 17 items. Main efficacy variable was the reduction percentage of 17 symptom score documented in PMSD during the luteal phase of the third treatment cycle. Results: A total of 67 patients were enrolled and randomly assigned to VAC group or placebo group. Of these, 64 patients completed the study (31 vs. 33). All the 17 symptoms showed a significantly greater improvement with VAC than placebo ( P < 0.05) except lower abdominal cramping ( P > 0.05). Conclusion: Vitex agnus castus is more effective than placebo in the treatment of moderate‐to‐severe PMS in Chinese women, especially in symptoms of negative effect and insomnia.