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Parental decisions regarding prenatally detected fetal sex chromosomal abnormality and the impact of genetic counselling: An analysis of 57 cases in Taiwan
Author(s) -
SHAW ShengWen,
CHUEH HoYen,
CHANG ShuennDyh,
CHENG PoJen,
HSIEH T'sangT’ang,
SOONG YungKuei
Publication year - 2008
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2008.00828.x
Subject(s) - abnormality , genetic counseling , chromosomal abnormality , fetus , psychology , medicine , obstetrics , developmental psychology , genetics , biology , psychiatry , pregnancy , chromosome , karyotype , gene
Objective: To analyse parental decisions regarding pregnancies with sex chromosome abnormalities (SCA). Methods: Collected and reviewed records from our hospital for 1991–2005. Genetic counselling was provided by obstetricians or perinatologists. Result: Among 57 fetuses with SCA were 36 non‐mosaic cases (four of 36, 45,X; 12 of 36, 47,XXY; seven of 36, 47,XYY, 13 of 36, 47,XXX) and 21 mosaic cases (15 of 21, 45,X mosaicism). Only 20% of 45,X mosaic pregnancies were continued, whereas all other mosaic pregnancies (100%) were continued ( P = 0.004). Of 32 SCA cases counselled by a perinatologist, 66% (21 of 32) were continued. In contrast, 36% (nine of 25) of cases counselled by a general obstetrician were continued, a barely significant difference ( P = 0.048). More couples chose to continue pregnancies in recent years. Conclusion: Genetic counselling by well‐trained specialists is valuable, and the trend towards fewer terminations at our centre suggests improved parental knowledge of pathology associated with SCA.