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Pathological interactions with the timing of birth and uterine activation
Author(s) -
SMITH Roger,
VAN HELDEN Dirk,
HIRST Jon,
ZAKAR Tamas,
READ Mark,
CHAN EngCheng,
PALLISER Hannah,
GRAMMATOPOULOS Dimitris,
NICHOLSON Richard,
PARKINGTON Helena C.
Publication year - 2007
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2007.00775.x
Subject(s) - corollary , pathological , medicine , preterm labor , mechanism (biology) , neuroscience , pregnancy , psychology , biology , gestation , genetics , mathematics , pure mathematics , philosophy , epistemology
The physiological processes that regulate the onset of parturition and birth are slowly being elucidated, and the points at which pathology can intervene are becoming more apparent. The data support the view that multiple pathways lead to myometrial activation. The clinical corollary is that combinations of tocolytics that operate via different mechanisms may be more effective than single agents. It may also be necessary to divide preterm labour into groups based on underlying mechanisms and to tailor therapy accordingly.