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Reduction in protein S activity during normal pregnancy
Author(s) -
KURASAWA Gotaro,
KOTANI Kazuhiko,
ITO Yuji,
SAIGA Kyoko,
IIJIMA Kenji
Publication year - 2007
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2007.00720.x
Subject(s) - pregnancy , reduction (mathematics) , medicine , endocrinology , obstetrics , chemistry , biology , genetics , geometry , mathematics
We investigated the serial changes in blood protein S (PS) and related proteins in 11 normal pregnant women. The PS activity decreased significantly in the third trimester and reached minimum levels (23.3%) one hour after delivery. Although the PS activity was reduced markedly below the normal limits, all the women delivered safely. The mechanisms that cause the reduction in PS activity and the clinically dangerous conditions involving PS activity during pregnancy warrant further investigation.