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The genetic basis of premature ovarian failure
Author(s) -
WOAD Kathryn J.,
WATKINS Wendy J.,
PRENDERGAST Deborah,
SHELLING Andrew N.
Publication year - 2006
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2006.00585.x
Subject(s) - premature ovarian failure , hypoestrogenism , amenorrhea , infertility , medicine , premature menopause , gynecology , menopause , biology , pregnancy , genetics
Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.