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Identification and characterisation of human endometrial stem/progenitor cells
Author(s) -
GARGETT Caroline E.
Publication year - 2006
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2006.00582.x
Subject(s) - stromal cell , progenitor cell , stem cell , clonogenic assay , biology , endometrium , amniotic epithelial cells , progenitor , adult stem cell , microbiology and biotechnology , endothelial stem cell , cell culture , cancer research , endocrinology , in vitro , genetics
The human endometrium is a dynamic, cyclically regenerating tissue. Because adult stem cells are present in other regenerative tissues, a clonal analysis of purified endometrial epithelial and stromal cells derived from hysterectomy tissue was undertaken, as a first attempt to identify and characterise endometrial stem/progenitor cells. Rare populations of epithelial and stromal cells were clonogenic. Only those cells initiating large clones, 0.09% of epithelial cells and 0.02% of stromal cells, are likely to be endometrial stem/progenitor cells.