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Effects of coasting on the outcome of intracytoplasmic sperm injection‐embryo transfer cycles
Author(s) -
AKTAN Erdal,
BOZKURT Kaan,
OZER Dilek,
YUCEBILGIN Sait,
KARADADAS Nedim,
BILGIN Onur
Publication year - 2004
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.2004.00226.x
Subject(s) - intracytoplasmic sperm injection , controlled ovarian hyperstimulation , embryo transfer , gynecology , ovarian hyperstimulation syndrome , pregnancy , pregnancy rate , medicine , retrospective cohort study , andrology , embryo , in vitro fertilisation , live birth , obstetrics , biology , genetics
Objectives: To determine the effects of ‘coasting’ on the outcome of controlled ovarian hyperstimulation (COH) and intracytoplasmic sperm injection–embryo transfer (ICSI–ET). Design: Retrospective study. Setting: IVF Centre, Ozel Ege Tup Bebek Merkezi, Izmir, Turkey. Sample: Twenty‐six coasted and 52 non‐coasted COH and ICSI–ET patients were enrolled in this retrospective study. Methods: Coasted patients were enrolled consecutively during the study period, and two non‐coasted controls were selected from our database for each coasted patient. Coasting was decided when serum oestradiol level was ≥4000 pg/mL. Groups were compared using χ 2 and Mann–Whitney U ‐tests for statistical analysis. Main Outcome Measures: Number of oocytes collected, metaphase II (MII) oocytes and cleaving embryos, the fertilisation rate and clinical pregnancy rate were the main outcome measures. Results: Number of oocytes collected, number of MII oocytes, number of cleaving embryos, fertilisation rate and clinical pregnancy rate for the coasted and non‐coasted groups were 15.5 ± 5.2 and 14.0 ± 7.1, 9.7 ± 4.8 and 9.3 ± 3.9, 6.8 ± 3.9 and 5.8 ± 3.1, 0.85 ± 0.18 and 0.78 ± 0.18, 13/26 and 24/52, respectively; these differences were not statistically significant. None of the patients in the coasted group were hospitalised for signs or findings of severe ovarian hyperstimulation syndrome. Conclusions: Coasting does not adversely affect the number and the function of mature oocytes and the clinical pregnancy rate.