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Oral Methotrexate in the Management of Refractory Interstitial Cystitis
Author(s) -
A. Moran Paul,
L. Dwyer Peter,
P. Carey Marcus,
F. Maher Christopher,
J. Radford Nicolas
Publication year - 1999
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1999.tb03135.x
Subject(s) - interstitial cystitis , medicine , methotrexate , refractory (planetary science) , adverse effect , urology , bladder pain syndrome , prospective cohort study , urinary system , urinary bladder , anesthesia , surgery , physics , astrobiology
Summary: To establish the safety and efficacy of low‐dose oral methotrexate in treating refractory interstitial cystitis, 9 women who fulfilled internationally accepted criteria for the diagnosis of interstitial cystitis were enrolled in a prospective study. All had proven unresponsive to conventional treatment modalities. Assessment by pain score and frequency volume charts was performed pretreatment and up to 6 months during therapy. No significant adverse side effects were noted. At the end of follow‐up, 4 women had noted a subjective improvement in bladder pain and wished to continue on methotrexate, 4 women noted little change and 1 woman reported a worsening of symptoms. Overall there was a significant reduction in pain score (p = 0.047) posttreatment. However, there was no significant difference in urinary frequency per 24 hours (p = 0.40), maximum voided volume (p = 0.089) or mean voided volume (p = 0.59). Methotrexate significantly improved bladder pain in women with interstitial cystitis, although no significant change was found in voiding pattern.