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Early Stage Cervical Cancer: A Multivariate Analysis of Histopathological Prognostic Factors
Author(s) -
Allen D.G.,
Roovers J.P.W.R.,
Lindert A.C.M.,
Heintz A.P.M.
Publication year - 1994
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1994.tb01109.x
Subject(s) - parametrial , lymph node , stage (stratigraphy) , medicine , lymph , cervical cancer , cervix , univariate analysis , pathology , carcinoma , cancer , multivariate analysis , oncology , cervical carcinoma , biology , paleontology
Summary: A multivariate analysis of the histopathological prognostic factors in early stage carcinoma of the cervix was performed. A total of 140 patients were studied (Stage 1A 6, Stage IB 107, Stage 2A 27 patients). Five‐year follow‐up data were available for 124 patients and 10‐year data for 76 patients. The histopathological factors considered were the histological type, lymph node metastases, tumour diameter, lymph vascular space invasion, parametrial invasion and corpus and vaginal invasion. Multivariate analysis identified lymph node metastases (p = 0.0003) and tumour diameter (p = 0.0016) as significant variables for survival at 5 and 10 years. There was a high incidence of occult parametrial invasion (20% in Stage IB and 37% in Stage 2A). Univariate analysis identified lymph node metastases (p < 0.0001), tumour diameter (p < 0.0001), lymph vascular space invasion (p = 0.0041) and parametrial invasion (p = 0.0024) as significant variables for survival at 5 years, with lymph node metastases, tumour diameter, lymph vascular space invasion remaining significant at 10 years. If there were 2 or more pelvic lymph node metastases the survival decreased considerably (up to 40% over 5 years). Microscopic parametrial invasion was identified in 20% of Stage IB and 37% of Stage 2A tumours. The critical period for recurrence was the first 2 years after surgery.