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Indomethacin for the Treatment of Polyhydramnios: A Case of Constriction of the Ductus Arteriosus
Author(s) -
MBBS Diane Mohen,
MD John P. Newnham,
D'Orsogna Luigi
Publication year - 1992
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1992.tb01957.x
Subject(s) - polyhydramnios , constriction , medicine , ductus arteriosus , fetus , gestation , amniotic fluid , obstetrics , cardiology , anesthesia , surgery , pregnancy , genetics , biology
Summary: Prenatal administration of indomethacin for the treatment of polyhydramnios at 27 weeks' gestation resulted in the rapid restoration of normal amniotic fluid volume. However, after 16 days therapy, fetal echocardiography revealed constriction of the fetal ductus arteriosus which did not reverse during the 17 days after the therapy was discontinued. The constriction resulted in right heart failure but no long‐term effects on the infant after birth. Indomethacin is a powerful treatment for polyhydramnios but its use requires close monitoring of the fetal heart.