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The Effect of Consanguinity on Pregnancy‐Induced Hypertension
Author(s) -
George Korula,
Vedamony Jeya,
Idikulla John,
Rao P. S. S.
Publication year - 1992
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1992.tb01953.x
Subject(s) - consanguinity , etiology , inbreeding , odds ratio , medicine , pregnancy , incidence (geometry) , consanguineous marriage , pediatrics , obstetrics , confidence interval , genetic counseling , demography , population , genetics , biology , environmental health , physics , optics , sociology
Summary: The aetiology of pregnancy induced hypertension (P1H) is unknown. Either an immunological or a genetic disorder are considered likely, with possibly an interaction between the two. If this were true, homozygosity would play an important role. Though consanguinity is believed to play a protective role, the effect of inbreeding on PIH has been inadequately studied. In South India consanguinity is common (26%). We prospectively studied 814 primigravidas of whom 213 had consanguineous marriages The proportion of women who developed PIH was compared in the 2 groups of women with consanguineous and nonconsanguineous marriages. The odds of a patient with PIH being consanguineous was 1.12 with a 95% confidence interval of 0.72‐1.75. Our observations suggest that consanguinity does not influence the incidence of PIH.