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Langerhans Cell Population in Early Invasive Squamous Cell Carcinoma Of The Uterine Cervix
Author(s) -
Tay Sun Kuie,
Jenkins David
Publication year - 1989
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1989.tb02873.x
Subject(s) - immunoperoxidase , pathology , langerhans cell , cervix , epithelium , carcinoma , cell , population , medicine , biology , antibody , cancer , immunology , antigen , monoclonal antibody , environmental health , genetics
Summary: Langerhans cell counts were performed using indirect immunoperoxidase staining for S100 protein in 10 cases of early invasive squamous cell carcinoma of the cervix and 20 controls from routine hysterectomy specimens. There was a significant (p<0.01) reduction in the number of Langerhans cells per unit sectional area of tumour tissue compared to the normal cervical epithelium. The density of Langerhans cells in the 3 patients with tumour metastasis in pelvic lymph nodes was further reduced. The low density of Langerhans cells in invasive squamous cell carcinoma compared to the normal state may reflect poor local immunosurv‐eillance and may be related to progression and spread of the tumour.