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Insulin‐like Growth Factor 1 as an Intra‐ovarian Hormone — an Integrated Hypothesis and Review
Author(s) -
Eden John A.,
Carter Graham D.,
Jones Julia,
AlaghbandZadeh Jamshid
Publication year - 1989
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1989.tb02872.x
Subject(s) - medicine , endocrinology , follicular fluid , follicular phase , luteinizing hormone , insulin like growth factor , growth factor , hormone , follicle , biology , receptor , oocyte , embryo , microbiology and biotechnology
Summary: Fourteen ovulatory patients undergoing diagnostic laparoscopy had at least 2 samples of clear follicular fluid (FF) collected in the late follicular phase. Dominant follicles contained significantly higher concentrations of insulin‐like growth factor‐1 (IGF1), oestradiol (E2), progesterone (P) and lower androstendione (AD) than their matched cohorts. After the luteinizing hormone (LH) surge, a significant increase in dominant FF‐IGF1 and FF‐P occurred. Log FF‐E2 and log FF‐P were correlated with both FF‐IGF1 and FF volume. Log FF‐AD was negatively correlated with FF‐volume, FF‐E2 and FF‐P (but not FF‐IGF1). The cohort concentration of FF‐IGF1 was correlated with serum IGF1. These results support the hypothesis that IGF1 has a central role in the selection of the dominant follicle.