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Failure of Chloroquine Malaria Prophylaxis in Pregnancy
Author(s) -
Mola Glen L.,
Wanganapi Alex
Publication year - 1987
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1987.tb00926.x
Subject(s) - chemoprophylaxis , chloroquine , malaria , pregnancy , medicine , plasmodium falciparum , malaria prophylaxis , obstetrics , new guinea , pediatrics , immunology , biology , genetics , history , ethnology
EDITORIAL COMMENT: Failure of chloroquine for malaria prophylaxis is important, if not alarming, for residents and visitors, especially pregnant women, in these areas. Summary: Women in a hyperendemic malarious area of Papua New Guinea are supplied with weekly chloroquine chemoprophylaxis at antenatal clinics. A study of 180 women in late pregnancy failed to show any difference in Plasmodium falciparum parasite rates between regular and irregular clinic attenders. Nor was anaemia in late pregnancy associated with parasitaemia; however, grandmultiparas exhibited significantly more prevalent parasitaemia and anaemia in late pregnancy. This study reveals a need for a more detailed investigation of the effects and usefulness of chemoprophylaxis with chloroquine in areas where P. falciparum chloroquine resistance is present.