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Antenatal Screening for Congenital Infection with Rubella, Cytomegalovirus and Toxoplasma
Author(s) -
Sfameni Salvatore F.,
Skurrie Ian J.,
Gilbert Gwendolyn L.
Publication year - 1986
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1986.tb01582.x
Subject(s) - cytomegalovirus , toxoplasmosis , medicine , rubella , asymptomatic , pregnancy , incidence (geometry) , rubella virus , antibody , toxoplasma gondii , immunology , obstetrics , cytomegalovirus infection , pediatrics , virology , human cytomegalovirus , viral disease , herpesviridae , virus , vaccination , biology , measles , genetics , physics , optics
Summary: The sera of 3,463 pregnant women were screened, at the first antenatal visit, for antibodies to rubella, cytomegalovirus (CMV) and Toxoplasma gondii. Rubella antibodies were detected in 97.5%, CMV antibodies in 71% and toxoplasma antibodies in 45% of women. Asymptomatic toxoplasmosis occurred during pregnancy in 3 of 609 (0.5%) and primary CMV infection in 5 of 338 (1.5%) initially seronegative women whose sera were retested at the end of their pregnancies. The observed incidence of toxoplasmosis was similar to that calculated on the basis of the age‐related prevalence of antibodies found in this study. On the basis of these observations it is estimated that congenital toxoplasmosis and congenital CMV infection due to primary maternal infection each occurs in up to 2/1,000 infants in this community. Very few of these infants have obvious abnormalities at birth, but follow‐up studies elsewhere have shown that many of them suffer significant long‐term sequelae.