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A Comparison of Circulating Immune Complexes, Pregnancy Associated β1‐Macroglobulin and Galactosyltransferase as Tumour Markers for Ovarian Cancer
Author(s) -
Dodd J.,
Davey R. A.,
McAdam A.,
Stimson W. H.,
Fay R.,
Crandon A. J.,
Hicks L.,
Tyler J. P. P.,
Hudson C. N.
Publication year - 1986
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1986.tb01567.x
Subject(s) - ovarian cancer , galactosyltransferase , medicine , disease , immune system , pregnancy , cancer , oncology , immunology , biology , biochemistry , genetics , enzyme
Summary: Serial blood samples have been obtained from 12 patients with ovarian cancer who were treated by surgery and, generally, chemotherapy or radiotherapy. Some achieved clinical remission, but the majority relapsed after a variable time interval. Three potential tumour markers (Circulating Immune Complexes, Pregnancy Associated β1‐Macroglobulin and Galactosyltransferase) have been studied longitudinally in serum for clinical correlation, predictive value, and biochemical ‘lead time’ to clinically detectable progression. None of the 3 offered any signal advantage over the others, and each showed an inconsistent relationship to observed disease status, with high levels indicating a poor outlook and the converse not true. Thus, since the ‘lead time’ is short, and reliability low, none of the compounds can be strongly commended as individual markers for ovarian cancer.