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The Incidence of Cytomegalic Inclusion Disease (CID) in an Obstetric Teaching Hospital, 1975–1984
Author(s) -
Hatherley Lawrence I.
Publication year - 1985
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1985.tb00637.x
Subject(s) - medicine , cytomegalic inclusion disease , incidence (geometry) , cytomegalovirus , pediatrics , cytomegalovirus infection , disease , pregnancy , fetus , obstetrics , human cytomegalovirus , viral disease , immunology , virus , herpesviridae , physics , biology , optics , genetics
Summary: A low incidence (1 in 4,000) of neonatal CID was found in 47,320 consecutive live births at an obstetric hospital over a decade. The mortality was high, 5 of 16 neonates died in hospital and, of those discharged, 7 were left with severe cerebral and/or ophthalmic handicaps. Minor, remediable conditions were also found in 7 infants. Previous studies have indicated that CMV infection occurs in 1–2% of all pregnancies and 10% of the infected neonates have signs of CID at birth. A highly significant increase in the incidence of antenatal complications was found in mothers delivered of cytomegalovirus (CMV)‐infected infants which may have compounded the effects of the viral disease on the fetus. A CMV‐specific defect in the maternal and neonatal immune systems is discussed.