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An Incremental‐Dose Combined Oestrogen‐Progestogen Oral Contraceptive: Cycle Control and Endometrial Changes
Author(s) -
Khoo S. K.,
McKenna H.
Publication year - 1980
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1980.tb02900.x
Subject(s) - progestogen , endometrium , menstrual cycle , norgestrel , medicine , genitourinary system , metrorrhagia , menstruation , physiology , estrogen , hormone , gynecology , endocrinology , population , family planning , research methodology , environmental health
Summary: A study of bleeding patterns and endometrial histology was made in women using an incremental‐dose combined oestrogen‐progestogen formulation. The proliferative activity during the first 11 days of treatment was less well‐developed, and there was an early appearance of secretory changes (transitional pattern). The increased dose of d‐norgestrel resulted in an endometrium showing either early or deficient secretory changes. Menstrual patterns were very satisfactory in terms of cycle length and duration of bleeding.