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Prenatal Diagnosis of Placental Sulphatase Deficiency
Author(s) -
Phillipou G.,
Seamark R. F.,
Sweet R.
Publication year - 1979
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1979.tb01381.x
Subject(s) - urine , dehydroepiandrosterone , endocrinology , medicine , fetus , steroid sulfatase , pregnancy , chemistry , steroid , biology , hormone , androgen , genetics
Summary: A gas chromatographic procedure for the quantitation of neutral steroid sulphates in maternal urine and its application to a suspected case of placental sulphatase deficiency is described. Low levels of oestriol coincident with elevated 16‐hydroxylated metabolites of dehydroepiandrosterone in the maternal urine are shown to occur in this particular condition, and thus provide a convenient differentiation from fetal adrenal hypoplasia before birth.