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Prostaglandins and Postmaturity
Author(s) -
TambyRaja R. L.,
Karim S. M. M.,
Salmon J. A.,
Ratnam S. S.
Publication year - 1977
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1977.tb02636.x
Subject(s) - prostaglandin , pregnancy , amniotic fluid , cervical dilatation , medicine , obstetrics , endocrinology , prostaglandin f , prostaglandin e , term (time) , fetus , biology , cervix , physics , genetics , cancer , quantum mechanics
Summary: Levels of E and F prostaglandins in amniotic fluid of patients with prolonged pregnancy have been compared with levels of patients in the last 4 weeks of normal pregnancy. The mean F prostaglandin levels in patients going past term (1,293.3 ± 332.87 pg/ml) were considerably lower than those going into spontaneous labour at term (4,276.71 ± 1,469.62 pg/ml). In 43 patients who went past term, the F prostaglandin levels bore a positive correlation to the cervical score (correlation coefficient 0.654; P < 0.001). These studies suggest that prostaglandins play an important role in the spontaneous onset of labour at term and are also responsible for cervical ripening at term.