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Plasma Fibrinolytic Activity in Early Pregnancy
Author(s) -
Condie Roy G.
Publication year - 1976
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1976.tb02575.x
Subject(s) - medicine , gestation , venous stasis , pregnancy , plasminogen activator , fibrinolysis , venous blood , gynecology , obstetrics , endocrinology , biology , genetics
Summary: In an attempt to elucidate changes in the fibrinolytic mechanism in early pregnancy, a prospective study was carried out on six nulliparous women from the time of stopping oral contraception until 16 weeks of gestation. A venous stasis stress test was applied at each sampling, and plasminogen activator levels were assayed in peripheral venous plasma. A significant reduction in fibrinolytic activity from the prepregnant level did not occur until 16 weeks of gestation in the unstressed situation, and until 12 weeks in the stressed situation. In both the prepregnant and pregnant states the stress of venous stasis effected a significant release of activator on each occasion of testing.