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Gonadotrophin Stimulation for Oocyte Recovery and in Vitro Fertilization in Infertile Women
Author(s) -
Talbot J. M.,
Dooley M.,
Leeton J.,
Lopata A.,
McMaster R.,
Wood C.,
Brown J. B.,
Evans J. H.
Publication year - 1976
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1976.tb02366.x
Subject(s) - pregnanediol , in vitro fertilisation , ovulation , oocyte , follicular phase , endocrinology , medicine , andrology , excretion , hormone , gynecology , biology , pregnancy , embryo , microbiology and biotechnology , genetics
Summary: The effects of gonadotrophin stimulation were investigated by urinary oestrogen and pregnanediol analyses and by timed laparoscopic examination in 14 infertile ovulatory women with total tubal destruction who were candidates for in vitro oocyte fertilisation. An unpredictable ovarian response was obtained in 6 patients when a fixed regimen of 4 doses of FSH followed by HCG was used as described by Steptoe and Edwards (1970). Therapy was then changed in 8 patients to larger daily doses of FSH which were monitored by urinary oestrogen excretion and HCG was given according to the response. This regimen resulted in hormone excretion patterns which resembled those found during the normal ovulatory cycle except that oestrogen peak values were higher. The laparoscopic findings were consistent with the hormone values and information was obtained relating the timing of ovulation to the patterns of oestrogen and pregnanediol excretion. It is hoped that these findings can be applied to the improved collection of follicular oocytes of optimum maturity for in vitro fertilisation.