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Urinary Hydroxyproline in Pregnancy — An Index of Placental Function A Preliminary Report
Author(s) -
Eachempati Uma,
Ostapowicz Frank,
Lazzara Joseph V.
Publication year - 1975
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1975.tb00862.x
Subject(s) - hydroxyproline , urinary system , pregnancy , placental insufficiency , medicine , placenta , vascularity , diabetes mellitus , obstetrics , endocrinology , gynecology , physiology , biology , fetus , surgery , genetics
Summary: The range of total urinary hydroxyproline was determined by 71 assays on 36 women with normal pregnancies. In addition, 103 assays were performed on 58 women with complicated pregnancies. There was a gradual increase in values up to 36 weeks in normal pregnancy, with a fall towards term. In patients with placental insufficiency due to such conditions as marked hypertension and diabetes, high values were obtained in those with a successful outcome of the pregnancy, which seemed to be indicative of compensatory increased vascularity of the placenta. A lack of this rise was seen in those in whom intrauterine death occurred. It is suggested that total urinary hydroxyproline assay may be useful as an additional parameter for assessing placental function.