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Intravenous Diazoxide in the Treatment of Severe Pre‐Eclamptic Toxaemia and Eclampsia
Author(s) -
Michael C. A.
Publication year - 1973
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1973.tb02296.x
Subject(s) - diazoxide , eclampsia , medicine , diazepam , blood pressure , anesthesia , convulsion , pregnancy , obstetrics , epilepsy , biology , insulin , genetics , psychiatry
Summary: Forty‐nine patients with severe pre‐eclampsia and 4 patients with eclampsia were treated with the hypotensive drug diazoxide combined with diaze‐pam. In all patients a satisfactory reduction and subsequent control of the blood pressure occurred. There was no maternal mortality and the perinatal mortality was 13%. After administration of the above drugs no eclamptic convulsion occurred or recurred. It is felt that the combination of diazoxide with diazepam is more effective in controlling an elevated blood pressure in labour than the previous conventional administration of heavy sedatives with their associated maternal and fetal hazards.