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Intravenous Chlormethiazole in the Management of Severe Pre‐Eclampsia
Author(s) -
Tischler E.
Publication year - 1973
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1973.tb02295.x
Subject(s) - eclampsia , medicine , anesthesia , clearance , pregnancy , biology , genetics , urology
Summary: Intravenous chlormethiazole in combination with hydralazine and epidural analgesia was used in the management of 25 patients with severe pre‐eclampsia in the last 8 weeks of pregnancy. Chlormethiazole is a potent anti‐convulsant and no eclamptic fits occurred. Phlebitis at the site of infusion and maternal and neonatal hypothermia were the most common side effects observed. Accidental overdosage was not followed by respiratory depression. Comparison with a similar group of patients treated with the lytic cocktail showed no significant difference in the condition of babies at birth. Fetal salvage, however, was better in the chlormethiazole‐treated group. Chlormethiazole crosses the placenta. It is rapidly cleared from the maternal bloodstream, but persists in the neonatal circulation in considerable concentration during the first 24 hours of life.