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Abortifacient Action of Prostaglandins with Particular Reference to the Use of PGF2α Administered into the Amniotic Sac in the Second Trimester of Pregnancy
Author(s) -
Shearman Rodney,
Korda Andrew,
Smith Ian
Publication year - 1972
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1972.tb02338.x
Subject(s) - hysterotomy , medicine , vomiting , abortion , pregnancy , nausea , abortifacient , obstetrics , cervix , second trimester , anesthesia , gestation , gynecology , genetics , cancer , biology
SUMMARY The results of the intra‐amniotic administration of prostaglandin F 2a to 117 patients for the termination of second trimester pregnancy are recorded. The mean induction‐abortion interval was 23.7 hours, with a range of 5 to 61 hours in 111 successful cases. The induction‐abortion interval was influenced by parity and time of administration of the PGF 2a , but not by the gestational age of the pregnancy. There were 6 failures (5.1 % of cases treated) and of these, only one patient required hysterotomy. Abortion was complete in 74 patients and obviously incomplete in 37 patients. There was a high incidence of systemic sideeffects, however they were transient. The most common side‐effects were nausea, vomiting and diarrhoea, dyspnoea, sweating and skin flushing. There were two cases of cervical damage; one involved bilateral lacerations and the other a bucket handle rupture of the cervix.